Research.

My scientific career has followed an unconventional trajectory from chemical engineering, through chemical biology and epigenetics to directed evolution. My research applies fundamental chemical and quantitative approaches to complex systems in an attempt to understand and manipulate the molecular vulnerabilities of disease.

 
Flexible open-source automation for robotic bioengineeringChory & Gretton et al. (BioRxiv) 2020

Flexible open-source automation for robotic bioengineering

Chory & Gretton et al. (BioRxiv) 2020

A high-throughput platform for feedback-controlled directed evolutionDebenedictis & Chory et al. (BioRxiv) 2020

A high-throughput platform for feedback-controlled directed evolution

Debenedictis & Chory et al. (BioRxiv) 2020

Nucleosome Turnover Regulates Histone Methylation Patterns over the GenomeChory et al. (Molecular Cell) 2020

Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome

Chory et al. (Molecular Cell) 2020

 
Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell KillingChory et al. (ACS Chem Bio) 2020

Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing

Chory et al. (ACS Chem Bio) 2020

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Chemically induced proximity in biology and medicine

Stanton, Chory & Crabtree (Science) 2018

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitorsWu, Chory et al. (Nature Communications) 2012

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Wu, Chory et al. (Nature Communications) 2012

A high-throughput platform for assessing synergy of drug combinationsChory & Divakaran (Unpublished) 2019

A high-throughput platform for assessing synergy of drug combinations

Chory & Divakaran (Unpublished) 2019